Rybelsus vs. Trulicity

rybelsus vs trulicity

You’ve been diagnosed with type II diabetes. Now, you want to find the best medication to help you live your healthiest life. But with so many options available, how do you choose the right one? Rybelsus and Trulicity are currently two of the most widely prescribed medicines to treat type II diabetes. Here’s how they compare:

Type II Diabetes

When we eat, our bodies break more complex carbohydrates into a monosaccharide called glucose. Glucose is the body’s primary energy source. After eating, the glucose gets absorbed into our bloodstream. Our bodies recognize the rise in blood sugar levels and trigger our pancreas to release a hormone called insulin, which acts as a key to get glucose into our cells. As glucose moves into cells, blood sugar levels drop, and the pancreas decreases the amount of insulin it releases.

Type II Diabetes is a disease where your body no longer processes glucose correctly, leading to high blood sugar levels. This happens for one of two reasons: your pancreas may stop producing enough insulin to maintain healthy blood sugar levels, or your cells can become insulin resistant. Insulin-resistant cells absorb less sugar than they should, even if insulin levels remain constant.
Uncontrolled high blood sugar can cause several problems with your circulatory, nervous, and immune system.

Symptoms of diabetes can develop slowly over several years and may include:

  • Increased hunger or thirst
  • Frequent urination
  • Fatigue
  • Blurred vision
  • Unintended weight loss
  • Signs of immune insufficiency, such as frequent infections and slow-healing sores
  • Numbness or tingling in your extremities
  • Patches of darkened skin, especially around the armpits and neck

 

There is no cure for type II diabetes, but you can manage blood sugar levels through diet, exercise, and medications like Rybelsus.

About Rybelsus

Rybelsus is the brand name for the oral form of semaglutide. Semaglutide was first developed as a treatment for type II diabetes by the pharmaceutical company Novo Nordisk 2012. It underwent clinical trials in 2015 and was approved for use in 2017 under Ozempic. Ozempic was available as a once-weekly injection. While semaglutide was a highly effective type II diabetes treatment, it was not suitable for people who were uncomfortable or unable to inject themselves with a needle. In 2019, the FDA approved an oral tablet form
of the medication known as Rybelsus.

About Trulicity

Trulicity is the brand name for Eli Lilly’s GLP-1 Receptor Agonist (dulaglutide). The FDA first approved the once-weekly injection to help control type II diabetes in adults in September 2014. By the third quarter of 2019, Trulicity had become Eli Lilly’s most popular diabetes drug, and it was expected to become the top-selling diabetes medication worldwide by 2024. In February 2020, Trulicity was also approved to help reduce cardiovascular events in “adults with and without established cardiovascular disease.” The FDA also authorized additional doses of the drug that same year.

What is a GLP-1 Receptor Agonist

When we eat, our small intestines release a hormone called glucagon-like peptide 1 (GLP-1). The hormone travels to the pancreas, where it activates specialized receptors and triggers the release of insulin. A GLP-1 Receptor Agonist mimics this naturally occurring hormone to increase insulin levels, reduce glucagon release, delay gastric emptying, and suppress appetite. Not only does this lower blood sugar by ensuring that glucose is more effectively transported into cells, but it may also promote weight loss.

Dosage and Administration

Rybelsus

Rybelsus is available as an oral tablet in 7 mg and 14 mg doses. When you first start taking Rybelss, you’ll take one 3 mg tablet once a day for 30 days. After 30 days, you’ll switch to one 7 mg tablet once a day. If you still need more help controlling your blood pressure after 30 days on the 7 mg dose, your doctor might increase your dose to one 14 mg tablet once a day.

You will need to take your Rybelsus tablet with no more than 4 ounces of water first thing in the morning before you eat, drink, or take any other oral medications. Once you’ve taken Rybelsus, wait 30 minutes before ingesting anything else. It is important that you always swallow the tablet whole and never rush, split, or chew it. 

You can find more information on the dosages of Rybelsus by clicking here

Trulicity

Trulicity comes in pre-filled pens that are injected subcutaneously, meaning underneath the skin. Most professionals recommend starting with .75 mg once a week and then increasing to 1.5 mg weekly. If additional glycemic control is still needed after 4 weeks, you can increase the dose to 3 mg weekly. If you are still not seeing adequate improvement after another 4 weeks, you can increase to the maximum dosage of 4.5 mg per week.

You should administer your Trulicity injection into your abdomen, thigh, or upper arm once a week, at any time of day, with or without food. When you start taking Trulicity, your doctor will train you on proper injection techniques. If you also take insulin to manage your diabetes, administer the shots separately and never adjacent to each other. Rotate injection sites with each dose.

Effectiveness

Rybelsus

Rybelsus has been shown to be highly effective at reducing A1C—a measure of blood glucose levels—at both commercially available dosages. The American Diabetes Association recommends that adults with type II diabetes strive to keep their A1C at less than 7%. In a 6-month study, patients who took the 7 mg dose of Rybelsus saw an average decrease in their A1C levels of 1.2%. Nearly 7 out of 10 achieved an A1C of less than 7% by the conclusion of the study. Patients taking the 14 mg dose saw an average decrease of 1.4%, and nearly 8 out of 10 achieved an A1C lower than 7%.

Trulicity

In patients with a starting A1C between 8.0% and 8.6%, Trulicity helped between half to two-thirds achieve an A1C of less than 7% over 4 weekly doses.

Side Effects

Rybelsus

For the most part, Rybelsus causes mild side effects that mostly impact the digestive tract. However, on rare occasions, more serious side effects may occur.

Common side effects include: 

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Loss of appetite
  • Stomach pain

 

Serious side effects include: 

  • Hypoglycemia—very low blood sugar, resulting in weakness and fainting
  • Pancreatitis—inflammation of the pancreas that causes severe stomach pain, nausea, and vomiting
  • Vision changes
  • A type of cancer called medullary thyroid carcinoma and other thyroid tumors. Signs of thyroid tumors in clude a lump or swelling in your neck, hoarse voice, and difficulty swallowing.

Trulicity

Trulicity and Rybelsus share many similar side effects. The most common side effects of both affect the digestive tract. Trulicity can also cause more serious side effects than Rybelsus.

Common side effects include: 

  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Loss of appetite
  • Stomach pain

 

Serious side effects include:

  • Hypoglycemia—very low blood sugar, resulting in weakness and fainting
  • Pancreatitis—inflammation of the pancreas that causes severe stomach pain, nausea, and vomiting
  • A type of cancer called medullary thyroid carcinoma and other thyroid tumors. Signs of thyroid tumors include a lump or swelling in your neck, hoarse voice, and difficulty swallowing.
  • Kidney failure and other kidney problems
  • Severe allergic reactions, including anaphylaxis

How to Get Rybelsus

Ready to start using Rybelsus to treat your diabetes? Here’s how.

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Step 1: Talk to a Doctor

Rybelsus is only available with a prescription. Talk to a doctor about your symptoms to determine if Rybelsus is right for you.

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Step 2: Find a Pharmacy Near You

Due to high demand, not every pharmacy may have Rybelsus in stock, which can delay your treatment. BuyRybelsus.com can help you locate your closest provider so you can start treatment as soon as possible.

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Step 3: Pick Up Your Prescription and Take as Directed

Get your life and A1C back under control with Rybelsus!